Publications

Yanginlar, C., Rother, N., Post, T. G. J. M., Jacobs, M., Jonkman, I., Brouns, M., Rinzema, S., Martens, J. H. A., Vermeulen, M., Joosten, L. A. B., Netea, M. G., Hilbrands, L. B., Choudhry, Z. A., van der Vlag, J., & Duivenvoorden, R. (2024). Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus. Journal of autoimmunity, 149, 103335. https://doi.org/10.1016/j.jaut.2024.103335

Berendsen, M. L. T., Bles, P., de Bree, L. C. J., Jensen, K. J., Jensen, C. C., Wejse, C., Mendes, D. V., Netea, M. G., & Benn, C. S. (2024). Bacillus Calmette-Guérin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau. Vaccine, 42(26), 126439. https://doi.org/10.1016/j.vaccine.2024.126439

Lercher, A., Cheong, J. G., Bale, M. J., Jiang, C., Hoffmann, H. H., Ashbrook, A. W., Lewy, T., Yin, Y. S., Quirk, C., DeGrace, E. J., Chiriboga, L., Rosenberg, B. R., Josefowicz, S. Z., & Rice, C. M. (2024). Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease. Immunity, 57(11), 2530–2546.e13. https://doi.org/10.1016/j.immuni.2024.08.018

Jacobs, M. M. E., Maas, R. J. F., Jonkman, I., Negishi, Y., Tielemans Zamora, W., Yanginlar, C., van Heck, J., Matzaraki, V., Martens, J. H. A., Baltissen, M., Vermeulen, M., Morla-Folch, J., Ranzenigo, A., Wang, W., Umali, M., Ochando, J., van der Vlag, J., Hilbrands, L. B., Joosten, L. A. B., Netea, M. G., … Duivenvoorden, R. (2024). Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling. Cell reports, 43(9), 114664. https://doi.org/10.1016/j.celrep.2024.114664

Sun, S. J., Aguirre-Gamboa, R., de Bree, L. C. J., Sanz, J., Dumaine, A., van der Velden, W. J. F. M., Joosten, L. A. B., Khader, S., Divangahi, M., Netea, M. G., & Barreiro, L. B. (2024). BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses. Immunity, 57(9), 2095–2107.e8. https://doi.org/10.1016/j.immuni.2024.07.021

Tran, K. A., Pernet, E., Sadeghi, M., Downey, J., Chronopoulos, J., Lapshina, E., Tsai, O., Kaufmann, E., Ding, J., & Divangahi, M. (2024). BCG immunization induces CX3CR1^hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity. Nature immunology, 25(3), 418–431. https://doi.org/10.1038/s41590-023-01739-z

Moorlag, S. J. C. F. M., Folkman, L., Ter Horst, R., Krausgruber, T., Barreca, D., Schuster, L. C., Fife, V., Matzaraki, V., Li, W., Reichl, S., Mourits, V. P., Koeken, V. A. C. M., de Bree, L. C. J., Dijkstra, H., Lemmers, H., van Cranenbroek, B., van Rijssen, E., Koenen, H. J. P. M., Joosten, I., Xu, C. J., … Bock, C. (2024). Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity. Immunity, 57(1), 171–187.e14. https://doi.org/10.1016/j.immuni.2023.12.005

Fok, E. T., Moorlag, S. J. C. F. M., Negishi, Y., Groh, L. A., Dos Santos, J. C., Gräwe, C., Monge, V. V., Craenmehr, D. D. D., van Roosmalen, M., da Cunha Jolvino, D. P., Migliorini, L. B., Neto, A. S., Severino, P., Vermeulen, M., Joosten, L. A. B., Netea, M. G., Fanucchi, S., & Mhlanga, M. M. (2024). A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation. Nature genetics, 56(1), 85–99. https://doi.org/10.1038/s41588-023-01598-2

van Puffelen, J. H., Novakovic, B., van Emst, L., Kooper, D., Zuiverloon, T. C. M., Oldenhof, U. T. H., Witjes, J. A., Galesloot, T. E., Vrieling, A., Aben, K. K. H., Kiemeney, L. A. L. M., Oosterwijk, E., Netea, M. G., Boormans, J. L., van der Heijden, A. G., Joosten, L. A. B., & Vermeulen, S. H. (2023). Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections. Journal for immunotherapy of cancer, 11(1), e005518. https://doi.org/10.1136/jitc-2022-005518

Li, W., Moorlag, S. J. C. F. M., Koeken, V. A. C. M., Röring, R. J., de Bree, L. C. J., Mourits, V. P., Gupta, M. K., Zhang, B., Fu, J., Zhang, Z., Grondman, I., van Meijgaarden, K. E., Zhou, L., Alaswad, A., Joosten, L. A. B., van Crevel, R., Xu, C. J., Netea, M. G., & Li, Y. (2023). A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity. Cell reports, 42(5), 112487. https://doi.org/10.1016/j.celrep.2023.112487

Schrijver, D. P., Röring, R. J., Deckers, J., de Dreu, A., Toner, Y. C., Prevot, G., Priem, B., Munitz, J., Nugraha, E. G., van Elsas, Y., Azzun, A., Anbergen, T., Groh, L. A., Becker, A. M. D., Pérez-Medina, C., Oosterwijk, R. S., Novakovic, B., Moorlag, S. J. C. F. M., Jansen, A., Pickkers, P., … Mulder, W. J. M. (2023). Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells. Nature biomedical engineering, 7(9), 1097–1112. https://doi.org/10.1038/s41551-023-01050-0

Bannister, S., Kim, B., Domínguez-Andrés, J., Kilic, G., Ansell, B. R. E., Neeland, M. R., Moorlag, S. J. C. F. M., Matzaraki, V., Vlahos, A., Shepherd, R., Germano, S., Bahlo, M., Messina, N. L., Saffery, R., Netea, M. G., Curtis, N., & Novakovic, B. (2022). Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes. Science advances, 8(31), eabn4002. https://doi.org/10.1126/sciadv.abn4002

Kaufmann, E., Khan, N., Tran, K. A., Ulndreaj, A., Pernet, E., Fontes, G., Lupien, A., Desmeules, P., McIntosh, F., Abow, A., Moorlag, S. J. C. F. M., Debisarun, P., Mossman, K., Banerjee, A., Karo-Atar, D., Sadeghi, M., Mubareka, S., Vinh, D. C., King, I. L., Robbins, C. S., … Divangahi, M. (2022). BCG vaccination provides protection against IAV but not SARS-CoV-2. Cell reports, 38(10), 110502. https://doi.org/10.1016/j.celrep.2022.110502

Kong, L., Moorlag, S. J. C. F. M., Lefkovith, A., Li, B., Matzaraki, V., van Emst, L., Kang, H. A., Latorre, I., Jaeger, M., Joosten, L. A. B., Netea, M. G., & Xavier, R. J. (2021). Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes. Cell reports, 37(7), 110028. https://doi.org/10.1016/j.celrep.2021.110028

Divangahi, M., Aaby, P., Khader, S. A., Barreiro, L. B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A. R., Dominguez-Andres, J., Duivenvoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K. L., Khan, N., Joosten, L. A. B., Kaufmann, E., Latz, E., … Netea, M. G. (2021). Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nature immunology, 22(1), 2–6. https://doi.org/10.1038/s41590-020-00845-6

de Bree, L. C. J., Mourits, V. P., Koeken, V. A., Moorlag, S. J., Janssen, R., Folkman, L., Barreca, D., Krausgruber, T., Fife-Gernedl, V., Novakovic, B., Arts, R. J., Dijkstra, H., Lemmers, H., Bock, C., Joosten, L. A., van Crevel, R., Benn, C. S., & Netea, M. G. (2020). Circadian rhythm influences induction of trained immunity by BCG vaccination. The Journal of clinical investigation, 130(10), 5603–5617. https://doi.org/10.1172/JCI133934

Koeken, V. A., de Bree, L. C. J., Mourits, V. P., Moorlag, S. J., Walk, J., Cirovic, B., Arts, R. J., Jaeger, M., Dijkstra, H., Lemmers, H., Joosten, L. A., Benn, C. S., van Crevel, R., & Netea, M. G. (2020). BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner. The Journal of clinical investigation, 130(10), 5591–5602. https://doi.org/10.1172/JCI133935

Kalafati, L., Kourtzelis, I., Schulte-Schrepping, J., Li, X., Hatzioannou, A., Grinenko, T., Hagag, E., Sinha, A., Has, C., Dietz, S., de Jesus Domingues, A. M., Nati, M., Sormendi, S., Neuwirth, A., Chatzigeorgiou, A., Ziogas, A., Lesche, M., Dahl, A., Henry, I., Subramanian, P., … Chavakis, T. (2020). Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell, 183(3), 771–785.e12. https://doi.org/10.1016/j.cell.2020.09.058

Cirovic, B., de Bree, L. C. J., Groh, L., Blok, B. A., Chan, J., van der Velden, W. J. F. M., Bremmers, M. E. J., van Crevel, R., Händler, K., Picelli, S., Schulte-Schrepping, J., Klee, K., Oosting, M., Koeken, V. A. C. M., van Ingen, J., Li, Y., Benn, C. S., Schultze, J. L., Joosten, L. A. B., Curtis, N., … Schlitzer, A. (2020). BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. Cell host & microbe, 28(2), 322–334.e5. https://doi.org/10.1016/j.chom.2020.05.014

Khader, S. A., Divangahi, M., Hanekom, W., Hill, P. C., Maeurer, M., Makar, K. W., Mayer-Barber, K. D., Mhlanga, M. M., Nemes, E., Schlesinger, L. S., van Crevel, R., Vankayalapati, R., Xavier, R. J., Netea, M. G., & Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18 (2019). Targeting innate immunity for tuberculosis vaccination. The Journal of clinical investigation, 129(9), 3482–3491. https://doi.org/10.1172/JCI128877

Walk, J., de Bree, L. C. J., Graumans, W., Stoter, R., van Gemert, G. J., van de Vegte-Bolmer, M., Teelen, K., Hermsen, C. C., Arts, R. J. W., Behet, M. C., Keramati, F., Moorlag, S. J. C. F. M., Yang, A. S. P., van Crevel, R., Aaby, P., de Mast, Q., van der Ven, A. J. A. M., Stabell Benn, C., Netea, M. G., & Sauerwein, R. W. (2019). Outcomes of controlled human malaria infection after BCG vaccination. Nature communications, 10(1), 874. https://doi.org/10.1038/s41467-019-08659-3

Domínguez-Andrés, J., Novakovic, B., Li, Y., Scicluna, B. P., Gresnigt, M. S., Arts, R. J. W., Oosting, M., Moorlag, S. J. C. F. M., Groh, L. A., Zwaag, J., Koch, R. M., Ter Horst, R., Joosten, L. A. B., Wijmenga, C., Michelucci, A., van der Poll, T., Kox, M., Pickkers, P., Kumar, V., Stunnenberg, H., … Netea, M. G. (2019). The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Cell metabolism, 29(1), 211–220.e5. https://doi.org/10.1016/j.cmet.2018.09.003

Freyne, B., Donath, S., Germano, S., Gardiner, K., Casalaz, D., Robins-Browne, R. M., Amenyogbe, N., Messina, N. L., Netea, M. G., Flanagan, K. L., Kollmann, T., & Curtis, N. (2018). Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens. The Journal of infectious diseases, 217(11), 1798–1808. https://doi.org/10.1093/infdis/jiy069

Arts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S. Y., Oosting, M., Kumar, V., Xavier, R. J., Wijmenga, C., Joosten, L. A. B., Reusken, C. B. E. M., Benn, C. S., Aaby, P., Koopmans, M. P., Stunnenberg, H. G., van Crevel, R., & Netea, M. G. (2018). BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell host & microbe, 23(1), 89–100.e5. https://doi.org/10.1016/j.chom.2017.12.010

Bekkering, S., Arts, R. J. W., Novakovic, B., Kourtzelis, I., van der Heijden, C. D. C. C., Li, Y., Popa, C. D., Ter Horst, R., van Tuijl, J., Netea-Maier, R. T., van de Veerdonk, F. L., Chavakis, T., Joosten, L. A. B., van der Meer, J. W. M., Stunnenberg, H., Riksen, N. P., & Netea, M. G. (2018). Metabolic Induction of Trained Immunity through the Mevalonate Pathway. Cell, 172(1-2), 135–146.e9. https://doi.org/10.1016/j.cell.2017.11.025

Mitroulis, I., Ruppova, K., Wang, B., Chen, L. S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., Chatzigeorgiou, A., Schlitzer, A., Beyer, M., Joosten, L. A. B., Isermann, B., Lesche, M., Petzold, A., Simons, K., Henry, I., Dahl, A., … Chavakis, T. (2018). Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell, 172(1-2), 147–161.e12. https://doi.org/10.1016/j.cell.2017.11.034

Christ, A., Günther, P., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Haendler, K., Baßler, K., Klee, K., Schulte-Schrepping, J., Ulas, T., Moorlag, S. J. C. F. M., Kumar, V., Park, M. H., Joosten, L. A. B., Groh, L. A., Riksen, N. P., Espevik, T., … Latz, E. (2018). Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell, 172(1-2), 162–175.e14. https://doi.org/10.1016/j.cell.2017.12.013

Kaufmann, E., Sanz, J., Dunn, J. L., Khan, N., Mendonça, L. E., Pacis, A., Tzelepis, F., Pernet, E., Dumaine, A., Grenier, J. C., Mailhot-Léonard, F., Ahmed, E., Belle, J., Besla, R., Mazer, B., King, I. L., Nijnik, A., Robbins, C. S., Barreiro, L. B., & Divangahi, M. (2018). BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell, 172(1-2), 176–190.e19. https://doi.org/10.1016/j.cell.2017.12.031

Arts, R. J., Novakovic, B., Ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S. C., Wang, S. Y., Habibi, E., Gonçalves, L. G., Mesquita, I., Cunha, C., van Laarhoven, A., van de Veerdonk, F. L., Williams, D. L., van der Meer, J. W., Logie, C., O’Neill, L. A., … Netea, M. G. (2016). Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell metabolism, 24(6), 807–819. https://doi.org/10.1016/j.cmet.2016.10.008

Arts, R. J. W., Carvalho, A., La Rocca, C., Palma, C., Rodrigues, F., Silvestre, R., Kleinnijenhuis, J., Lachmandas, E., Gonçalves, L. G., Belinha, A., Cunha, C., Oosting, M., Joosten, L. A. B., Matarese, G., van Crevel, R., & Netea, M. G. (2016). Immunometabolic Pathways in BCG-Induced Trained Immunity. Cell reports, 17(10), 2562–2571. https://doi.org/10.1016/j.celrep.2016.11.011

Novakovic, B., Habibi, E., Wang, S. Y., Arts, R. J. W., Davar, R., Megchelenbrink, W., Kim, B., Kuznetsova, T., Kox, M., Zwaag, J., Matarese, F., van Heeringen, S. J., Janssen-Megens, E. M., Sharifi, N., Wang, C., Keramati, F., Schoonenberg, V., Flicek, P., Clarke, L., Pickkers, P., … Stunnenberg, H. G. (2016). β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell, 167(5), 1354–1368.e14. https://doi.org/10.1016/j.cell.2016.09.034

Netea, M. G., Joosten, L. A., Latz, E., Mills, K. H., Natoli, G., Stunnenberg, H. G., O’Neill, L. A., & Xavier, R. J. (2016). Trained immunity: A program of innate immune memory in health and disease. Science, 352(6284), aaf1098. https://doi.org/10.1126/science.aaf1098