2023-2024
Posted on 16 February 2026
Yanginlar, C., Rother, N., Post, T. G. J. M., Jacobs, M., Jonkman, I., Brouns, M., Rinzema, S., Martens, J. H. A., Vermeulen, M., Joosten, L. A. B., Netea, M. G., Hilbrands, L. B., Choudhry, Z. A., van der Vlag, J., & Duivenvoorden, R. (2024). Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus. Journal of autoimmunity, 149, 103335. https://doi.org/10.1016/j.jaut.2024.103335
Berendsen, M. L. T., Bles, P., de Bree, L. C. J., Jensen, K. J., Jensen, C. C., Wejse, C., Mendes, D. V., Netea, M. G., & Benn, C. S. (2024). Bacillus Calmette-Guérin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau. Vaccine, 42(26), 126439. https://doi.org/10.1016/j.vaccine.2024.126439
Lercher, A., Cheong, J. G., Bale, M. J., Jiang, C., Hoffmann, H. H., Ashbrook, A. W., Lewy, T., Yin, Y. S., Quirk, C., DeGrace, E. J., Chiriboga, L., Rosenberg, B. R., Josefowicz, S. Z., & Rice, C. M. (2024). Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease. Immunity, 57(11), 2530–2546.e13. https://doi.org/10.1016/j.immuni.2024.08.018
Jacobs, M. M. E., Maas, R. J. F., Jonkman, I., Negishi, Y., Tielemans Zamora, W., Yanginlar, C., van Heck, J., Matzaraki, V., Martens, J. H. A., Baltissen, M., Vermeulen, M., Morla-Folch, J., Ranzenigo, A., Wang, W., Umali, M., Ochando, J., van der Vlag, J., Hilbrands, L. B., Joosten, L. A. B., Netea, M. G., … Duivenvoorden, R. (2024). Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling. Cell reports, 43(9), 114664. https://doi.org/10.1016/j.celrep.2024.114664
Sun, S. J., Aguirre-Gamboa, R., de Bree, L. C. J., Sanz, J., Dumaine, A., van der Velden, W. J. F. M., Joosten, L. A. B., Khader, S., Divangahi, M., Netea, M. G., & Barreiro, L. B. (2024). BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses. Immunity, 57(9), 2095–2107.e8. https://doi.org/10.1016/j.immuni.2024.07.021
Tran, K. A., Pernet, E., Sadeghi, M., Downey, J., Chronopoulos, J., Lapshina, E., Tsai, O., Kaufmann, E., Ding, J., & Divangahi, M. (2024). BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity. Nature immunology, 25(3), 418–431. https://doi.org/10.1038/s41590-023-01739-z
Moorlag, S. J. C. F. M., Folkman, L., Ter Horst, R., Krausgruber, T., Barreca, D., Schuster, L. C., Fife, V., Matzaraki, V., Li, W., Reichl, S., Mourits, V. P., Koeken, V. A. C. M., de Bree, L. C. J., Dijkstra, H., Lemmers, H., van Cranenbroek, B., van Rijssen, E., Koenen, H. J. P. M., Joosten, I., Xu, C. J., … Bock, C. (2024). Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity. Immunity, 57(1), 171–187.e14. https://doi.org/10.1016/j.immuni.2023.12.005
Fok, E. T., Moorlag, S. J. C. F. M., Negishi, Y., Groh, L. A., Dos Santos, J. C., Gräwe, C., Monge, V. V., Craenmehr, D. D. D., van Roosmalen, M., da Cunha Jolvino, D. P., Migliorini, L. B., Neto, A. S., Severino, P., Vermeulen, M., Joosten, L. A. B., Netea, M. G., Fanucchi, S., & Mhlanga, M. M. (2024). A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation. Nature genetics, 56(1), 85–99. https://doi.org/10.1038/s41588-023-01598-2
van Puffelen, J. H., Novakovic, B., van Emst, L., Kooper, D., Zuiverloon, T. C. M., Oldenhof, U. T. H., Witjes, J. A., Galesloot, T. E., Vrieling, A., Aben, K. K. H., Kiemeney, L. A. L. M., Oosterwijk, E., Netea, M. G., Boormans, J. L., van der Heijden, A. G., Joosten, L. A. B., & Vermeulen, S. H. (2023). Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections. Journal for immunotherapy of cancer, 11(1), e005518. https://doi.org/10.1136/jitc-2022-005518
Li, W., Moorlag, S. J. C. F. M., Koeken, V. A. C. M., Röring, R. J., de Bree, L. C. J., Mourits, V. P., Gupta, M. K., Zhang, B., Fu, J., Zhang, Z., Grondman, I., van Meijgaarden, K. E., Zhou, L., Alaswad, A., Joosten, L. A. B., van Crevel, R., Xu, C. J., Netea, M. G., & Li, Y. (2023). A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity. Cell reports, 42(5), 112487. https://doi.org/10.1016/j.celrep.2023.112487
Schrijver, D. P., Röring, R. J., Deckers, J., de Dreu, A., Toner, Y. C., Prevot, G., Priem, B., Munitz, J., Nugraha, E. G., van Elsas, Y., Azzun, A., Anbergen, T., Groh, L. A., Becker, A. M. D., Pérez-Medina, C., Oosterwijk, R. S., Novakovic, B., Moorlag, S. J. C. F. M., Jansen, A., Pickkers, P., … Mulder, W. J. M. (2023). Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells. Nature biomedical engineering, 7(9), 1097–1112. https://doi.org/10.1038/s41551-023-01050-0